孙坚

孙坚

 学科:基础兽医学        
电话/传真:15820215217          
电子邮件:jiansun@scau.edu.cn
通讯地址:广州市天河区五山路483号365bet平台网址 510642        
教研室:药理教研室

个人详细情况

    孙坚,男,1984年6月出生于湖南省邵阳市,农业博士,青年教授。

    2012年在365bet在线官网获得兽医药理学与毒理学博士学位,2012年于美国爱荷华州立大学从事访问学者研究。近年来主持国家自然科学基金重大国际(地区)合作项目1项,参与十三五重点研发计划子课题2项,研究成果共发表 SCI论文59 篇,累计影响因子184,其中以第一作者/通信作者在《 Nature Microbiology》、《 Journal of Antimicrobial Chemotherapy》和《 Antimicrobial Agents and Chemotherapy》等国际著名杂志发表了 SCI 论文30 篇(二区以上 24 篇);获 2015 年广东省科学技术奖一等奖 1 项(排名第 14),入选 2016 年度广州市“珠江科技新星”,并于2017年度入选广东省“青年珠江学者”;申请国家发明专利 2 项,获软件著作权 1 项;在国际、国内学术会议作专题报告 3 次。

 

学历及培训经历:

2012/7-2013/7,美国爱荷华州立大学,博士后,合作导师:张启敬

2007/9–2012/6,365bet在线官网,基础兽医学,博士,导师:刘雅红

2003/9–2007/6,广西大学,动物医学,学士,导师:吴文德

 

工作经历:

2016/12-至今, 365bet在线官网,365bet平台网址,青年教授

2015/10-至今,365bet在线官网,365bet平台网址,副教授

2013/10-2015/9,365bet在线官网,365bet平台网址,讲师

 

研究领域:

动物源细菌耐药性的监测;耐药及传播机制研究;耐药性防控技术

 

承担科研项目情况:

•国家自然科学基金青年基金项目:动物源大肠杆菌HI2型多重耐药质粒流行特征及亚抑菌浓度抗生素对其传播的影响,2015.01-2017.12

•广州市珠江新星专项:IncHI2型质粒促进大肠杆菌生物被膜形成机制研究,2016/01-2018/12,

•国家自然科学基金重点国际(地区)合作研究项目:31520103918,质粒协助沙门菌的适应性及其机制研究,2016/01-2020/12

 

代表论著:(*通讯作者)(文献编写格式如下)

(1) Sun, Jian(#),Yang, Run-Shi(#),Zhang, Qijing,Feng, Youjun,Fang,Liang-Xing,Xia, Jing,Li, Liang,Lv, Xiao-Yue,Duan, Jia-Hong,Liao, Xiao-Ping(*),Liu, Ya-Hong(*),Co-transfer of blaNDM-5 and mcr-1 by an IncX3-X4 hybrid

plasmid in Escherichia coli.,Nat Microbiol,2016.9.26,1:16176~16176

(2) Sun, Jian(#),Fang, Liang-Xin(#),Wu, Zuowei,Deng, Hui,Yang, Rui-Shi,Li, Xing-Ping,Li, Shu-Min,Liao-Xiao-Ping,Feng, Youjun(*),Liu,Ya-Hong(*),Genetic Analysis of the IncX4 Plasmids: Implications for a Unique Pattern in the mcr-1 Acquisition,Scientific Reports,2017.2.1,7

(3) Zhou, Yu-Feng,Tao, Meng-Ting,Feng, Youjun,Yang, Run-Shi,Liao, Xiao-Ping,Liu, Ya-Hong,Sun, Jian(*),Increased activity of colistin in

combination with amikacin against Escherichia coli co-producing NDM-5 and MCR-1,Journal of Antimicrobial Chemotherapy,2017.2.20,72(4):0~0

(4) Chen, Yi,Hu, Daxing,Zhang, Qijing,Liao, Xiao-Ping,Liu, Ya-Hong(*),Sun, Jian(*),Efflux Pump Overexpression Contributes to Tigecycline Heteroresistance in Salmonella enterica serovar Typhimurium,Frontiers in Cellular and Infection Microbiology,2017.2.17,7:37

(5) Sun, Jian(#),Li, Xing-Ping(#),Yang, Run-Shi,Fang, Liang-Xing,Huo, Wei,Li, Shu-Min,Jiang, Peng,Liao, Xiao-Ping,Liu, Ya-Hong(*),Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring blaCTX-M-55 and mcr-1.,Antimicrobial Agents and Chemotherapy,2016.8.01,60(8):5014~5017

(6) Li, Xing-Ping,Fang, Liang-Xing,Song, Jia-Qi,Xia, Jing,Huo, Wei,Fang, Jin-Tao,Liao, Xiao-Ping,Liu, Ya-Hong,Feng, Youjun(*),Sun, Jian(*),Clonal spread of mcr-1 in PMQR-carrying ST34 Salmonella isolates from animals in China.,Scientific Reports,2016.12.5,6:38511~38511

(7) Yang, Run-Shi,Feng, Youjun,Lv, Xiao-Yue,Duan, Jia-Hong,Chen, Jing,Fang, Liang-Xing,Xia, Jing,Liao, Xiao-Ping,Sun, Jian(*),Liu, Ya-Hong(*),Emergence of NDM-5- and MCR-1-Producing Escherichia coli Clones ST648 and

ST156 from a Single Muscovy Duck (Cairina moschata).,Antimicrobial Agents and

Chemotherapy,2016.11.01,60(11):6899~6902

(8) Huang, Ting,Xu, Ying,Zeng, Jie,Zhao, Dong-Hao,Li, Liang,Liao, Xiao-Ping,Liu, Ya-Hong(*),Sun, Jian(*),Low-Concentration Ciprofloxacin Selects Plasmid-Mediated Quinolone Resistance Encoding Genes and Affects Bacterial Taxa in Soil Containing Manure.,Frontiers in Microbiology,2016.01.01,7:1730~1730

(9) Yang, Qiu E,Walsh, Timothy Rutland,Liu, Bao Tao,Zou, Meng Ting,Deng, Hui,Fang, Liang Xing,Liao, Xiao Ping,Sun, Jian(*),Liu, Ya Hong(*),Complete Sequence of the FII Plasmid p42-2, Carrying blaCTX-M-55, oqxAB, fosA3, and floR from Escherichia coli.,Antimicrob Agents Chemother,2016.7.01,60(7):4336~4338

(10) Fang, Liangxing,Li, Xingping,Li, Liang,Li, Shumin,Liao, Xiaoping,Sun, Jian(*),Liu, Yahong(*),Co-spread of metal and antibiotic resistance within ST3-IncHI2 plasmids from E. coli isolates of food-producing animals.,Scientific Reports,2016.5.4,6:25312~25312

(11) Chen, Mu-Ya,Lira, Felipe,Liang, Hua-Qing,Wu, Rui-Ting,Duan, Jia-Hong,Liao, Xiao-Ping,Martinez, Jose L,Liu, Ya-Hong(*),Sun, Jian(*),Multilevel selection of bcrABDR-mediated bacitracin resistance in Enterococcus faecalis from chicken farms.,Scientific Reports,2016.10.12,6:34895~34895

(12) Sun, Jian(#),Li, Liang(#),Liu, Baotao,Xia, Jing,Liao, Xiaoping,Liu,Yahong(*),Development of aminoglycoside and beta-lactamase resistance among intestinal microbiota of swine treated with lincomycin, chlortetracycline, and amoxicillin.,Front Microbiol,2014.01.01,5:580~580

(13) Sun, Jian(#),Deng, Hui(#),Li, Liang,Chen, Mu-Ya,Fang, Liang-Xing,Yang, Qiu-E,Liu, Ya-Hong(*),Liao, Xiao-Ping(*),Complete nucleotide sequence of cfr-carrying IncX4 plasmid pSD11 from Escherichia coli.,Antimicrob Agents Chemother,2015.1.01,59(1):738~741

(14) Sun, Jian(#),Xiao, Xia(#),Huang, Rui-Juan,Yang, Tao,Chen, Yi,Fang, Xi,Huang, Ting,Zhou, Yu-Feng,Liu, Ya-Hong(*),In vitro Dynamic Pharmacokinetic/Pharmacodynamic (PK/PD) study and COPD of Marbofloxacin against Haemophilus parasuis.,BMC Veterinary Research,2015.12.1,11:293~293

(15) Sun, J,Yuan, L,Zhu, L,He, L,Luo, X,Wang, R,Liu, Y(*),Pharmacokinetics and bioavailability of valnemulin in Muscovy ducks (Cairina moschata).,Br Poult Sci,2012.01.01,53(3):374~378

(16) Sun, Jian(#),Liao, Xiaoping(#),Li, Lulu,Yang, Yurong,Liu, Baotao,Wang, Yang,Zhu, Hengqian,Zhu, Limeng,Tu, Chunting,Liu, Yahong(*),Emergence of pandemic B2-O25b-ST131 Escherichia coli harbouring blaCTX-M-3, blaCTX-M-27 and qnrS1 genes.,J Med Microbiol,2011.11.01,60(Pt 11):1711~1712

(17) Gao, Rongsui(#),Hu, Yongfei(#),Li, Zhencui(#),Sun, Jian(#),Wang, Qingjing,Lin, Jingxia,Ye, Huiyan,Liu, Fei,Srinivas, Swaminath,Li, Defeng,Zhu, Baoli,Liu, Ya-Hong,Tian, Guo-Bao,Feng, Youjun(*),Dissemination and Mechanism for the MCR-1 Colistin Resistance.,PLoS Pathogens,2016.11.01,12(11):e1005957~e1005957

(18) Sun, Jian,Liao, Xiao-Ping,Liu, Ya-Hong(*),Feng, Youjun(*),One Health: An Approach to Resolving Antibiotic Resistance,Infect Dis Transl Med,2016.9.6,2(3):122~124

(19) Fang, Liang-Xing(#),Sun, Jian(#),Li, Liang,Deng, Hui,Huang,Ting,Yang, Qiu-E,Li, Xue,Chen, Mu-Ya,Liao, Xiao-Ping,Liu, Ya-Hong(*),Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.,International Journal of Antimicrobial Agents,2015.8.01,46(2):209~213

(20) Chen, Yi(#),Sun, Jian(#),Liao, Xiao-Ping,Shao, Yang,Li, Liang,Fang, iang-Xing,Liu, Ya-Hong(*),Impact of enrofloxacin and florfenicol therapy on the spread of OqxAB gene and intestinal microbiota in chickens.,Veterinary Microbiology,2016.8.30,192:1~9

(21) Xia, Jing(#),Sun, Jian(#),Cheng, Ke,Li, Liang,Fang, Liang-Xing,Zou, Meng-Ting,Liao, Xiao-Ping,Liu, Ya-Hong(*),Persistent spread of the rmtB 16S rRNA methyltransferase gene among Escherichia coli isolates from diseased food-producing animals in China.,Vet Microbiol,2016.5.30,188:41~46

(22) Xiao, Xia(#),Sun, Jian(#),Chen, Yi,Zou, Mengting,Zhao, Dong-Hao,Liu, Ya-Hong(*),Ex vivo pharmacokinetic and pharmacodynamic analysis of valnemulin against Mycoplasma gallisepticum S6 in Mycoplasma gallisepticum and Escherichia coli co-infected chickens.,Veterinary Journal,2015.4.01,204(1):54~59

(23) Deng, Hui(#),Sun, Jian(#),Ma, Jun,Li, Liang,Fang, Liang-Xing,Zhang, Qijing,Liu, Ya-Hong,Liao, Xiao-Ping(*),Identification of the multi-resistance gene cfr in Escherichia coli isolates of animal origin.,PLos One,2014.01.01,9(7):e102378~e102378

(24) Xiao, Xia(#),Sun, Jian(#),Yang, Tao,Fang, Xi,Wu, Dong,Xiong, Yan Q,Cheng, Jie,Chen, Yi,Shi, Wei,Liu, Ya-Hong(*),In vivo pharmacokinetic/pharmacodynamic profiles of valnemulin in an experimental intratracheal Mycoplasma gallisepticum infection model.,Antimicrobial Agents

and Chemotherapy,2015.7.01,59(7):3754~3760

(25) Yang, Qiu-E(#),Sun, Jian(#),Li, Liang,Deng, Hui,Liu, Bao-Tao,Fang, Liang-Xing,Liao, Xiao-Ping,Liu, Ya-Hong(*),IncF plasmid diversity in multi-drug resistant Escherichia coli strains from animals in China.,Frontiers in Microbiology,2015.01.01,6:964~964

(26) Yuan, Liguo(#),Sun, Jian(#),Wang, Rui,Sun, Lihua,Zhu, Lixiang,Luo, Xianyang,Fang, Binghu,Liu, Yahong(*),Pharmacokinetics and bioavailability of cefquinome in healthy ducks.,American Journal of Veterinary Research,2011.1.01,72(1):122~126

(27) Xiao, Xia(#),Sun, Jian(#),Yang, Tao,Fang, Xi,Cheng, Jie,Xiong, Yan Q,Liu, Ya-Hong(*),Pharmacokinetic/Pharmacodynamic Profiles of Tiamulin in an Experimental Intratracheal Infection Model of Mycoplasma gallisepticum.,Front Vet Sci,2016.01.01,3:75~75

(28) Xiao, Xia(#),Sun, Jian(#),Chen, Yi,Huang, Rui-Juan,Huang, Ting,Qiao, Guilin Gary,Zhou, Yu-Feng,Liu, Ya-Hong(*),In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis.,BMC Veterinary Research,2015.2.13,11:33~33

(29) Yang, Shou-Shen(#),Sun, Jian(#),Liao, Xiao-Ping,Liu, Bao-Tao,Li, Lu-Lu,Li, Liang,Fang, Liang-Xing,Huang, Ting,Liu, Ya-Hong(*),Co-location of the erm(T) gene and blaROB-1 gene on a small plasmid in Haemophilus parasuis of pig origin.,Journal of Antimicrobial Chemotherapy,2013.8.01,68(8):1930~1932

(22) Li, Liang(#),Sun, Jian(#),Liu, Baotao,Zhao, Donghao,Ma, Jun,Deng, Hui,Li, Xue,Hu, Fengyang,Liao, Xiaoping,Liu, Yahong(*),Quantification of lincomycin resistance genes associated with lincomycin residues in waters and soils adjacent to representative swine farms in China.,Frontiers in Microbiology,2013.01.01,4:364~364

(30) Zhang, Sen(#),Sun, Jian(#),Liao, Xiao-Ping,Hu, Qian-Jiang,Liu, Bao-Tao,Fang, Liang-Xing,Deng, Hui,Ma, Jun,Xiao, Xia,Zhu, Heng-Qian,Liu, Ya-Hong(*),Prevalence and plasmid characterization of the qnrD determinant in Enterobacteriaceae isolated from animals, retail meat products, and humans.,Microbial Drug Resistance,2013.8.01,19(4):331~335


写给学生的话:

    时刻保持谦卑的态度,向知识弯腰,向真理致敬,向科学膜拜!